Potential Role of Nuclear Factor κB in Diabetic Cardiomyopathy

نویسندگان

  • O. Lorenzo
  • B. Picatoste
  • S. Ares-Carrasco
  • E. Ramírez
  • J. Egido
  • J. Tuñón
چکیده

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.

Diabetes affects cardiac structure and function, and it has been suggested that diabetes leads to cardiomyopathy. Arachidonate 12/15-lipoxygenase (LOX) has been suggested to play an important role in atherogenesis and heart failure. However, the role of 12/15-LOX in diabetic cardiomyopathy has not been examined. In this study, we investigated the effects of cardiac 12/15-LOX on diabetic cardiom...

متن کامل

Proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy

Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. A...

متن کامل

The effect of resistance training with mesenchymal stem cell injection on TNF-α and kappa B nuclear factor levels in the cortex of streptozotocin-induced diabetic rats

Introduction: Neuropathy is the most common neurological complication of diabetes which affects the central nervous systems, especially the brain. The aim of this study was to investigate the effects of resistance training After Transplantation of stem cells on rate of TNF-α and NF-κB in cerebral Cortex of STZ-induced Diabetic Rats. Materials and Methods: : In this experimental study,...

متن کامل

Troxerutin protects against diabetic cardiomyopathy through NF-κB/AKT/IRS1 in a rat model of type 2 diabetes

Troxerutin is a bioflavonoid, which can be used to treat venous disorders, thrombosis and cerebrovascular diseases. Recent studies have demonstrated that it may also be used to prevent edemas. However, it is not known whether troxerutin protects against the cardiomyopathic complications of diabetes. In the present study, a rat model of type 2 diabetes was used to investigate the potential for t...

متن کامل

Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro

Objective(s): Naringin, an essential flavonoid, inhibits inflammatory response and oxidative stress in diabetes. However, whether naringin has beneficial effects on diabetic retinopathy (DR) remains unknown. Materials and Methods: Streptozotocin (STZ, 65 mg/kg) was intraperitoneally injected into male rats (8 weeks old weighting 200-250 g) to establish diabetic model, then naringin (20, 40 or 8...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2011  شماره 

صفحات  -

تاریخ انتشار 2011